08/01/12

Dr. Yoram Rudy Awarded $1.52M NIH Grant

Dr. Yoram Rudy was awarded a $1,520,000 four year grant (years 28-31 of the award) from the NIH, National Heart, Lung and Blood Institute, for the project “Inverse and Forward Problems in Electrocardiography.” Research under this grant is aimed at studying arrhythmia properties and mechanisms in humans, using a novel noninvasive imaging modality for cardiac arrhythmias (Electrocardiographic Imaging, ECGI) developed in our laboratory.


06/01/12

Stepping Beyond ECG: Electrocardiographic Imaging

Yoram Rudy, Fred Saigh distinguished professor and director of the Cardiac Bioelectricity and Arrhythmia Center at Washington University in St Louis, St Louis, USA, talked to Cardiac Rhythm News about the novel imaging technique, electrocardiographic imaging, which was developed in his laboratory.

Full Article


08/31/11

Dangerous arrhythmia analyzed in a heartbeat

Study shows noninvasive, fast way to map heart’s electrical activity in one heartbeat

This article features Dr. Yoram Rudy, and his lab members Junjie Zhang, Kavit A. Desouza, MD, Ramya Vijayakumar. CBAC members Phillip S. Cuculich, MD, Jane Chen, MD, Mitchell N. Faddis, MD, PhD and Timothy W. Smith, DPhil, MD are also mentioned.

Full Article


02/13/11

Graduate Students Pan Li and Junjie Zhang Awarded for Best Poster Presentations

Pan Li and Junjie Zhang, both trainees in the laboratory of Professor Yoram Rudy, received awards for best poster presentations in the 2011 Gordon Conference on Cardiac Arrhythmia Mechanisms (Galveston, February 13-18). Pan Li received first prize for his project “ A Model of the Cardiac Purkinje Action Potential and Calcium Cycling”. Junjie Zhang received second prize for the project “Characterization of Electrophysiologic Substrate in Post- Myocardial Infarction Patients using Noninvasive Electrocardiographic Imaging (ECGI)”.

Full Article


05/13/10

Dr. Yoram Rudy Distinguished Alumni Award from Case Western Reserve University

Yoram Rudy received the Distinguished Alumni Award from Case Western Reserve University for his contributions to basic science in biomedical engineering. The award was presented on October 22nd 2009,during celebrations of 40 years to the biomedical engineering department at Case Western.


05/13/10

Dr. Yoram Rudy Receives the 2010 Heart Rhythm Society Distinguished Scientist Award

Yoram Rudy, the Fred Saigh Distinguished Professor and Director of the Cardiac Bioelectricity and Arrhythmia Center (CBAC) is the recipient of the 2010 Heart Rhythm Society Distinguished Scientist Award. The award ceremony will take place in May, during the Annual Heart Rhythm Society scientific sessions in Denver, Colorado.

Image and link to Full Article

07/30/09

Dr. Yoram Rudy delivers theTawara Lecture in Kyoto, Japan, lectures in Taiwan, and celebrates Luo-Rudy model

Yoram Rudy delivered the Tawara Lecture “Cardiac Excitation and Arrhythmia in the Human Heart: Insights from Noninvasive ECG Imaging ( ECGI)” at the International Congress of Physiological Sciences (IUPS) in Kyoto, Japan, on July 30th, 2009. From August 2nd – 13th, Professor Rudy presented a series of invited lectures in Taiwan at the following universities: National Taiwan University in Taipei, National Cheng Kung University in Tainan, Providence University and National Chung Hsing Universities in Taichung. On August 2nd a National Workshop celebrated the 18 year anniversary of the publication of the Luo-Rudy model of the cardiac cell.

Full Article

06/30/09

Rudy Lab Awarded $1.9M NIH and $294K NSF Grants

Yoram Rudy was awarded a $1,900,000 four year grant (years 17-20 of the award) from the NIH, National Heart, Lung and Blood Institute, for the project “Cardiac Excitation and Arrhythmias”. Research under this grant explores the mechanisms at multiple scales (molecular, cellular, and tissue) of cardiac rhythm disorders that can lead to sudden death.

Dr. Rudy also received a three year $294,621 grant from the National Science Foundation, for the project “Modeling Spatial Organization of Cardiac Cell Function: Application to Calcium Waves and Arrhythmia”.


06/11/09

Congratulations to Yong Wang who defended successfully his Ph.D. Theses
(more accurately, passed with flying colors…..)

The Topics of Yong Wang's Thesis:

“Contributions to the Methodology of Electrocardiographic Imaging (ECGI) and  Application of ECGI to Study Mechanisms of Atrial Arrhythmia, Post Myocardial Infarction Electrophysiological Substrate, and Ventricular Tachycardia in Patients” (Recipient of the outstanding original paper award for 2006 in the Annals of Biomedical Engineering)

Yong Wang Thesis

05/19/09 Congratulations to Subham Ghosh who defended successfully his Ph.D. Theses
(more accurately, passed with flying colors…..)

The Topic of Subham Ghosh's Thesis:

“Electrocardiographic Imaging: Development Of A Non-Smooth Regularization Method And Clinical Application In Patients With Wolff-Parkinson-White Syndrome And Heart Failure”


2009

Dr. Hund Receives the Journal of Molecular and Cellular Cardiology Author's Prize

Dr. Thomas J. Hund, an alum of the Rudylab (Ph.D. 2004) won the 2008 Early-Career Authors Prize, designed to recognize outstanding papers published by early-career authors in the Journal of Molecular and Cellular Cardiology. The award publication is : T.J.Hund, K.F. Decker, E. Kanter, P.J. Mohler, P.A. Boyden, R.B. Schuessler, K.A. Yamada, Y. Rudy, "Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling”,  J of Molecular and Cellular Cardiology 2008;45:420-428.

Full Article


09/2008
05/2009

Dr. Rudy Elected to be the Hein J.J. Wellens Distinguished Professor

Yoram Rudy, Ph.D., F.A.H.A., F.H.R.S., The Fred Saigh Distinguished Professor of Engineering; Professor of Biomedical Engineering, Cell Biology & Physiology, Medicine, Radiology, and Pediatrics; Director of the Cardiac Bioelectricity and Arrhythmia Center (CBAC) was elected as the Hein J.J. Wellens Distinguished Professor in Cardiology at the University of Maastricht, The Netherlands. Professor Rudy conducted workshops on cardiac electrophysiology at the Cardiovascular Research Institute Maastricht (CARIM) during September 2008 and May 2009. He also hosted visiting scientists from Maastricht University in his Washington University laboratory as part of a CBAC – CARIM collaboration in heart research.

Full Article


08/2008

Dr. Rudy at the Hatter Cardiovascular Research Institute, Cape Town University, Africa

In August 2008, Dr. Rudy participated in a symposium “CARDIAC ARRHYTHMIAS AND SUDDEN DEATH: FROM GENES TO PREVENTION” at the Hatter Cardiovascular Research Institute of Cape Town University in South Africa. He presented two invited talks about the molecular basis of cardiac repolarization, and about Electrocardiographic Imaging (ECGI) of cardiac arrhythmias.

Full Article


08/06/08

Dr. Yoram Rudya awarded $1,362,285 four year grant

Dr. Yoram Rudy was awarded a $1,362,285 four year grant, (years 24-27 of a Merit Award to Dr. Rudy) from the NIH, National Heart, Lung and Blood Institute for his Inverse and Forward Problems in Electrocardiography project. Research under this grant will continue the development of Electrocardiographic Imaging (ECGI), a novel noninvasive imaging modality for Cardiac Electrophysiology and Arrhythmia. 


08/06/08

 

Thomas O'Hara awarded two year grant

Thomas O'Hara was awarded two-year grant from the Predoctoral Fellowship Program of the Midwest Affiliate Research Committee of the American Heart Association for his "Mathematical Model of Human Cardiac Ventricular Action Potential" project.


04/28/08

Jonathan Silva completes Ph.D.

We are pleased to announce that Jonathan Silva successfully completed his Ph.D. research. The title of his dissertation is: "Linking Molecular Dynamics of Ion Channels to the Cardiac Action Potential: Simulations of Wild Type and Mutant Iks”.


01/25/08

 

Measured Impulses

By Gwen Ericson (The Record)

Washington University School of Medicine’s quarterly magazine, Outlook, is published by the Office of Medical Public Affairs. Biomedical Engineering Professor Yoram Rudy’s Lab was featured as the Outlook Winter 2007 cover story.

Full Article


12/18/07

Former Rudy Lab students Charulatha Ramanathan and Ping Jia elected by CARIN'S Cleveland Business to "2007 forty under 40"

Charulatha Ramanathan and Ping Jia, co-founders of CardioInsight Technologies, were elected by CARIN'S Cleveland Business to " 2007 forty under 40". CardioInsight is developing Electrocardiographic Imaging (ECGI) as a clinical diagnostic tool. Charu and Ping are former Ph.D. students in the Rudy Lab.

Full Article


11/26/07

Livshitz at the 4th International Symposium of Cell/Biodynamics Simulation Project

Leonid Livshitz participated in the 4th International Symposium of Cell/Biodynamics Simulation Project. The symposium took place in Kyoto, Japan, November 12-13, 2007. He also delivered an invited presentation “Regulation of calcium and electrical alternans in cardiac myocytes” in the department of Physics of Kyoto University, November 15, 2007 and the department of Bio-Medical Eng. in Technion, Israel institute of Technology, Haifa, November 25, 2007.

Full Article


09/24/07

Workshop on Regulation of Transport Phenomena in the Cardiac System

Yoram Rudy participated in a Workshop on Regulation of Transport Phenomena in the Cardiac System. The workshop took place in Antalya, Turkey, September 16-20, 2007.

 


10/08/07

Cardiac Electrophysiology Society (CES) annual scientific sessions:
"Calcium Cycling: The Arrhythmia Connection"

Yoram Rudy is the President of the Cardiac Electrophysiology Society (CES) for 2007-08. In this capacity, he organizes the annual scientific sessions for these years. The 2007 meeetings is in Orlando, Florida, November 3rd. The program topic is "Calcium Cycling: The Arrhythmia Connection."

Detailed Program


09/20/07

Yong Wang Paper chosen as the Outstanding Original Paper for 2006 by the Annals of Biomedical Engineering

The paper "Application of the Method of Fundamental Solutions to Potential-based Inverse Electrocardiography" by Yong Wang andYoram Rudy had been chosen as the Outstanding Original Paper for 2006 in the Annals of Biomedical Engineering. The award carries a prise of $1500 that will be used to supportYong Wang (a Ph.D. student in the Rudy Lab) travel to a scientific meeting of his choice.


08/22/07

Rudy organized workshop on "Systems Approach to Understanding Electromechanical Activity in the Human Heart"

Yoram Rudy organized and chaired a workshop on "Systems Approach to Understanding Electromechanical Activity in the Human Heart" at the NIH-National Heart, Lung and Blood Institute(Washington D.C., August 20-21, 2007). Participants included 13 leading scientists in cardiac research. The workshop objectives were to discuss the state-of-the-art and identify challenges of intergrating knowledge from the molecular and cellular scales to the whole-heart level, where cardiac arrhythmias and heart failure occur. The workshop participants developed a list of recommendations for future research directions and NIH-NHLBI support.

Executive Summary


03/24/07

Leonid Livshitz wins first first prize at the Gordon Research Conference on Cardiac Arrhythmia Mechanisms

Leonid Livshitz won the first prize at the Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Ventura Beach, California, March 18 – 23, 2007. His poster was entitled "Regulations of Calcium and Electrical Alternans in Cardiac Myocytes: Role of CaMKII and Repolarizing Currents".

Poster (PDF)


12/28/06

Thomas O'Hara receives M.S. degree

Thomas O'Hara received his M.S. degree in Biomedical Engineering of Washington University in St. Louis.


10/18/06

Dr. Yoram Rudy appointed to the Board of Directors for the International Society for Computerized Electrocardiology (ISCE)

Dr. Yoram Rudy has been appointed to the Board of Directors for the International Society for Computerized Electrocardiology (ISCE) for the term 2006-2007. He was also a member of the Executive Scientific Board, as well as chaired a session at, the 8th International Dead Sea Symposium and the Rappaport Symposium, “Consensus and Controversy in Cardiac Arrhythmias”, Tel-Aviv, Israel, October 2006.


10/11/06

Charu Ramanathan and Ping Jia establish CardioInsight Technologies

Charu Ramanathan and Ping Jia, our former PhD students, established CardioInsight Technologies, a startup company for developing Electrocardiographic Imaging (ECGI) as a clinical diagnostic tool for cardiac arrhythmias.

Press Release


10/10/06

Gregory Faber completes Ph.D. research

We are pleased to announce that Gregory Faber successfully completed his Ph.D. research. The title of his dissertation is: "A Model of L-type Ca2+ Channel - Ryanodine Receptor Interaction in the Restricted Space in a Cardiac Ventricular Myocyte”.


10/09/06

Lina El-Esbe receives the Dr. Yoram Rudy Scholarship

Congratulations to Lina El-Esber who received The Dr. Yoram Rudy Scholarship for the 2006-2007 academic year . Contributors to this scholarship fund are Mr. and Mrs. Jerome Brasch.


06/2006

Rudy delivered keynote and invited presentations in England, Germany and France

Yoram Rudy, the Fred Saigh Distinguished Professor of Engineering and Director of the Cardiac Bioelectricity and Arrhythmia Center (CBAC), delivered in June, 2006 two keynote presentations describing his work on noninvasive Electrocardiographic Imaging at the annual meetings of the International Society for Heart Research (Manchester, UK) and the International Congress on Electrocardiology (Cologne, Germany).

Professor Rudy also delivered an invited presentation at Cardiostim - World Congress in Cardiac Electrophysiology and Cardiac Techniques (Nice, France) on the role of potassium ion channels in cardiac repolarization and its dependence on the channels' molecular structure.


05/12/06

 

Rudy Lab in the first inaugural Cardiac Bioelectricity & Arrhythmia Center (CBAC) Research Retreat

The first inaugural Cardiac Bioelectricity & Arrhythmia Center (CBAC) Research Retreat was held on Friday, May 12, 2006 in Whitaker Hall at Washington University in St. Louis.

More Information


02/20/06

Dr. Yoram Rudy delivers the SPIE Medical Imaging Conference Keynote Presentation in San Diego

Dr. Yoram Rudy delivered the Keynote Presentation “Electrocardiographic Imaging (ECGI): a new noninvasive imaging modality for cardiac electrophysiology and arrhythmia” at the SPIE Medical Imaging Conference in San Diego , February 11-16, 2006. Yoram also delivered an invited plenary presentation “Modeling Cardiac Arrhythmias” at a Keystone Symposium on Cardiac Arrhythmias: Linking Structural Biology to Gene Defects in Tahoe City, California, January 29-February 3, 2006


02/10/06

Congratulations to Raja Ghanem!

Raja Ghanem is a winner of the Heart Rhythm Journal Outstanding Publication Award for Young Electrophysiologists for the paper “Noninvasive Electrocardiographic Imaging (ECGI): Comparison to Intraoperative Mapping in Patients” Heart Rhythm Journal 2005;2:339-354, by R.N. Ghanem, P. Jia, C. Ramanathan, K. Ryu, A. Markowitz, and Y. Rudy. This paper reports on work conducted as part of Raja’s Ph.D. Dissertation in our laboratory.

Abstract


12/10/05

Closer to the heart

This is a great article featuring Dr. Yoram Rudy in the faculty profile section of the Record.

Full Article


11/18/05

Charu Ramanathan at the American Heart Association Scientific Sessions

Charu Ramanathan presented an abstract “Noninvasive Electrocardiographic Imaging of Normal Human Activation and Repolarization” in the American Heart Association Scientific Sessions, Dallas, Nov. 2005.


11/18/05

Greg Faber at the American Heart Association Scientific Sessions

Greg Faber presented an abstract “Calsequestrin Mutation Results in Spontaneous Calcium Release and Delayed Afterdepolarizations in a Model of the Cardiac Ventricular Myocyte” in the American Heart Association Scientific Sessions, Dallas, Nov. 2005.


11/10/05

Visiting scientist
Professor Andras Varro

Visiting scientist Professor Andras Varro (University of Szeged, Hungary),Tom O'Haraand Dr. Yoram Rudy (seated left to right) meet in the lab conference room to discuss efforts in our ongoing research collaboration.


10/11/05

Dr. Yoram Rudy delivered the Kazuo Yamada Lecture

Dr. Yoram Rudy Ph.D., F.A.H.A., The Fred Saigh Distinguished Professor of Engineering, delivered the Kazuo Yamada Lecture titled “Noninvasive Electrocardiographic Imaging (ECGI) of Cardiac Electrophysiology and Arrhythmia” to the Japanese Society of Electrocardiology in Toyama, Japan on October 7, 2005. He also conducted a workshop on the molecular and genetic basis of cardiac arrhythmias in Nagoya, Japan on October 10, 2005.


10/10/05

Congratulations to Lina El-Esber

Congratulations to Lina El-Esber who received The Dr. Yoram Rudy Scholarship for the 2005-2006 academic year [contributors to this scholarship fund are Mr. and Mrs. Jerome Brasch]. Lina is a graduate student in the Department of Biomedical Engineering at Washington University; she works on her Ph.D. thesis in our laboratory.


05/27/05

Dr. Yoram Rudy gives lecture to the Technion Chapter of St. Louis

Presentation on "Research Towards Understanding and Preventing Irregular Heart Rhythms and Sudden Death" given by Dr. Yoram Rudy to the Technion Chapter of St. Louis.


03/17/05

Dr. Yoram Rudy visiting professor at Johns Hopkins University

Dr. Yoram Rudy was The Reynolds Visiting Professor at the Reynolds Center for Cardiovascular Research, Division of Cardiology, Johns Hopkins University . Yoram presented recent work on Electrocardiographic Imaging in humans


02/25/05

Rudy lab members win awards at the Gordon Research Conference on Cardiac Arrhythmia Mechanisms

Jonathan Silva won first place in the research competition at the Gordon Research Conference on Cardiac Arrhythmia Mechanisms (Buellton, California, February 20-25). The title of his poster was "Molecular Interactions Determine Effects of Iks on the Cardiac Action Potential: Modulation by KCNE1 and Chromanol 293b". Subham Ghosh was a third- place winner with the poster "Electrocardiographic Imaging (ECGI) of Cardiac Electrophysiology in Humans" – congratulations to both.

In the same meeting, Leonid Livshitz presented a poster on "Interactive Tool for Cell Model Simulation" and Thomas Hund on "Altered Calcium-Handling and Electrophysiological Remodeling in Cells from Infarcted Myocardium". Dr. Yoram Rudy gave a talk on “Modeling the Electrophysiological Consequences of Sodium Channel Dysfunction".


02/02/05

New math model of heart cell has novel calcium pathway

Advance helps in arrythmia research

Dr. Yoram Rudy's lab developed the first mathematical model of a canine cardiac cell that incorporates a vital calcium regulatory pathway that has implications in life-threatening cardiac arrhythmias, or irregular heartbeats.

This article also features members of the Rudy Lab: Thomas Hund, Yong Wang, Leonid Livshitz


11/30/04

New model of the canine cardiac ventricular cell

We have recently published a new model of the canine cardiac ventricular cell that includes the CaMKII regulatory pathway of calcium cycling. The paper resulted from Tom Hund's Ph.D. Thesis and was published in Circulation 2004; 110:3168-3174.

Full Article


11/22/04

Installation of CBAC Director Yoram Rudy as the Fred Saigh Distinguished Professor of Engineering

Yoram Rudy, Ph.D., professor of biomedical engineering in the School of Engineering & Applied Science, was installed as the inaugural Fred Saigh Distinguished Professor of Engineering in a ceremony Nov. 22 in Uncas A. Whitaker Hall for Biomedical Engineering.

Full Article


04/22/04

What's Next: Beyond the EKG, to a Hypersensitive Heart Monitor

by Anne Eisenberg (NY Times)

Dr. Yoram Rudy, Director of the Cardiac Bioelectricity and Arrhythmia Center (CBAC) at Washington University in St. Louis, has, over the past 20 years, developed a unique method of electrocardiographic imaging (ECGI) that provides a noninvasive and detailed technique for recording electrical activity of the heart. This new method has great potential of one day helping to identify and diagnose patients at high risk of sudden cardiac death and life-threatening arrhythmias.

Full Article

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