Rudy Lab Research
Overview
Overview | Mission | Goals | Research Interests | Dr. Rudy's Biography

 

Research Interests

Cardiac bioelectricity; cardiac electrophysiology and arrthymias; computational biology and mathematical modeling; cardiac imaging and mapping

Current Research

My research aims at understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various levels, from the molecular (ion channel) and cellular to the whole heart. We are also developing a novel noninvasive imaging modality (Electrocardiographic Imaging, ECGI) for the diagnosis and guided therapy of cardiac arrhythmias. Rhythm disorders of the heart lead to over 400,000 cases of sudden death annually in the US alone, and to many more cases of disability and compromised quality of life. Through the development of detailed mathematical models of cardiac cells (the Luo-Rudy model) and tissue, we are investigating the mechanisms and consequences of genetically-inherited cardiac arrhythmias, impaired cell-to-cell communication, and abnormal spread of the cardiac impulse in the diseased heart (e.g. myocardial infarction). ECGI imaging is currently being tested and evaluated with excellent results in patients with various heart conditions, including comparisons to muti-electrode mapping directly from the heart conditions, including comparisons to muti-electrode mapping directly from the heart during open-heart surgery. Our premise is that an integrated approach to the study of mechanisms at all levels of the cardiac systems, and the development of novel diagnostic tools, will lead to successful strategies for prevention and treatment of cardiac arrhythmias and sudden death.

Representative Peer-Review Publications

Modeling Cardiac Excitation

C. Luo and Y. Rudy, "A Dynamic Model of the Cardiac Ventricular Action Potential: I. Simulations of Ionic Currents and Concentration Changes” Circulation Research 1994; 74: 1071-1096.

C. E. Clancy, Y. Rudy, "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia" Nature 1999;400:566-569.

C.E. Clancy, Y. Rudy, “A Na+ Channel Mutation that Causes Both Brugada and Long QT Syndrome Phenotypes: A Simulation Study of Mechanism” Circulation 2002;105:1208-1213.

R.M. Shaw and Y. Rudy, "Electrophysiologic Effects of Acute Myocardial Ischemia: A Theoretical Study of Altered Cell Excitability and Action Potential Duration" Cardiovascular Research 1997; 35: 256-272

P.C. Viswanathan, R.M. Shaw, Y. Rudy, "Effects of Ikr and Iks Heterogeneity on Action Potential Duration and its Rate - Dependence: A Simulation Study" Circulation 1999; 99:2466-2474.

J. Zeng and Y. Rudy, "Early Afterdepolarizations in Cardiac Myocytes: Mechanism and Rate Dependence” Biophys J 1995; 68: 949-964.

G.M. Faber, Y. Rudy, “Action Potential and Contractility Changes in [Na+]i Overloaded Cardiac Myocytes: A Simulation Study” Biophys J 2000; 78:2392-2404.

W. Quan and Y. Rudy, "Unidirectional Block and Reentry of Cardiac Excitation–A Model Study” Circulation Research 1990; 66: 367-382.

R.M. Shaw and Y. Rudy, "Elecrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure" Circ Res 1997 ; 80:124-138.

R.M. Shaw and Y. Rudy, “Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-Type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling” Circ Res 1997; 81:727-741.

Y. Wang, Y. Rudy, "Action Potential Propagation in Inhomogeneous Cardiac Tissue: Safety Factor Considerations and Ionic Mechanism" Am J Physiol (Heart) 2000;278:H1019-H1029.

T. J. Hund, N.F. Otani, Y. Rudy, “The Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Ionic Mechanisms” Am J Physiol (Heart) 2000; 279:H1869-H1879.

J.P. Kucera, Y. Rudy, “Mechanistic Insights into Very Slow Conduction in Branching Cardiac Tissue: A Model Study” Circ Res 2001; 89:799-806.

J.P. Kucera, S. Rohr, Y. Rudy, “Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction” Circulation Research 2002; 91:1176-1182.

A.G. Kleber, Y. Rudy, “Basic Mechanisms of Cardiac Impulse Propagation and Reentrant Arrhythmias” Physiological Reviews 2004; 84:431-488

Electrocardiographic Imaging

C. Ramanathan, R.N. Ghanem, P. Jia, K. Ryu, Y. Rudy, “Electrocardiographic Imaging (ECGI): A Noninvasive Imaging Modality for Cardiac Electrophysiology and Arrhythmia” Nature Medicine 2004; 10: 422 - 428.

K. Gima, Y. Rudy, “ Ionic Current Basis of Electrocardiographic Waveforms: A Model Study “ Circulation Research 2002;90:889-896.

H.S.Oster, B.Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy, "Noninvasive Electrocardiographic Imaging: Reconstruction of Epicardial Potentials, Electrograms and Isochrones, and Localization of Single and Multiple Electrocardiac Events" Circulation 1997; 96: 1012-1024.

H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy, “Electrocardiographic Imaging: Noninvasive Characterization of Intramural Myocardial Activation from Inverse Reconstructed Epicardial Potentials and Electrograms” Circulation 1998; 97:1496-1507.

J.E. Burnes, B. Taccardi, R.S. MacLeod, Y. Rudy, "Noninvasive Electrocardiographic Imaging of Electrophysiologically Abnormal Substrate in Infarcted Hearts: A Model Study" Circulation 2000;101:533-540.

J. E. Burnes, B. Taccardi, Y. Rudy, “A Noninvasive Imaging Modality for Cardiac Arrhythmias” Circulation 2000; 102:2152-2158.

J. E. Burnes, B. Taccardi, P. Ershler, Y. Rudy, “Noninvasive ECG Imaging of Substrate and Intramural Ventricular Tachycardia in Infarcted Hearts” J Amer College Cardiol (JACC) 2001;38:2071-2078.

R.N. Ghanem, J.E. Burnes A.L. Waldo, Y. Rudy, “ Electrocardiographic Imaging: Noninvasive Reconstruction of Epicardial Measures of Dispersion of Repolarization” Biomedizinische Technik 2001;46:201-203.

C. Ramanathan, Y. Rudy, “Electrocardiographic Imaging:II. Effect of Torso Inhomogeneities on the Noninvasive Reconstruction of Epicardial Potentials, Electrograms and Isochrones” J Cardiovasc Electrophysiol 2001; 12:241-252.

C. Ramanathan, P. Jia, R.N. Ghanem, D. Calvetti, Y. Rudy, “Noninvasive Electrocardiographic Imaging (ECGI): Application of the Generalized Minimal Residual (GMRes) Method” Annals of Biomedical Engineering 2003; 31:981-994.

P. Jia, B.Punske, B.Taccardi, Y.Rudy, “Endocardial Mapping of Electrophysiologically Abnormal Substrates and Cardiac Arrhythmias using a Noncontact Nonexpandable Catheter” J Cardiovasc Electrophysiol 2002;13:888-895.

Active Grant Support

NATIONAL INSTITUTE OF HEALTH
R37-HL033343   
    07/01/85-05/31/2016      “Inverse and Forward Problems in Electrocardiography”, this grant was selected for an NIH MERIT Award.
     
NATIONAL INSTITUTE OF HEALTH 
RO1-HL049054
    02/01/93-11/30/2017 “Cardiac Excitation and Arrhythmias”
     

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