Overview | Mission | Goals | Research Interests | Dr. Rudy's Biography


Yoram Rudy

Current Position at Washington University in St. Louis

The Fred Saigh Distinguished Professor of Biomedical Engineering
Director, Cardiac Bioelectricity and Arrhythmia Center (CBAC)
Professor of Cell Biology & Physiology, Medicine, Pediatrics, and Radiology

Previous Position at Case Western Reserve University

The M. Frank and Margaret C. Rudy Professor of Cardiac Bioelectricity
Director, Cardiac Bioelectricity Research and Training Center (CBRTC)
Professor of Biomedical Engineering, Physiology and Biophysics, and Medicine


Technion, Haifa, Israel, B.Sc., 1971, Physics
Technion, Haifa, Israel, M.Sc., 1973, Physics
Case Western Reserve University, School of Medicine, 1 year, 1976
Case Western Reserve University, Ph.D., 1978, Biomedical Engineering

Honors and Awards

Member of the National Academy of Engineering
Citation: “For leadership in the engineering sciences of cardiac excitation at the genetic and molecular levels and for introducing new methods in clinical diagnosis and therapy”
NIH MERIT Award, September, 1998
The Biomedical Engineering Society (BMES) 2001 Distinguished Lectureship Award
Fellow of the American Physiological Society
Citation: "For outstanding research contributions in the field of cardiac electrophysiology"
Fellow of the Institute of Electrical and Electronics Engineers (IEEE)
Citation: "For contributions to mathematical descriptions and solutions applicable to cardiac electrophysiology"
Fellow of the American Institute of Medical and Biological Engineering (AIMBE)
Citation: "In recognition of outstanding contributions to the field of medical and biological engineering"
The Gordon K Moe Professorship Award, Masonic Medical Research Laboratory, 1997.
Citation: “In recognition of outstanding contributions to science and medicine in the fields of cardiac electrophysiology and arrhythmias”
The A.C. Suhren Jr. Scholar, Tulane University, 1998.
Keynote Address, Biomedical Engineering Day, Washington University in St. Louis, March, 2001.
The Rijlant Distinguished Lecturer, International Congress on Electrocardiology, Milan,
Italy, 2000.
The Ueda Memorial Lecture Award, The Japanese Society of Electrocardiology and
Japan College of Cardiology, Nagoya, Japan, September 2002.
Sigma Xi
Who's Who in America
Who's Who in Science and Engineering
Who's Who in the World

Visiting Professorships

Technion - Israel Institute of Technology, Haifa, Israel, Department of Biomedical Engineering (Dec. 1982 - Mar. 1983).
University of Parma, Italy, Institute of General Physiology (July 1986 and July 1987).
University of Berne, Switzerland, Department of Physiology (May 1990).
University of Utah, Salt Lake City, The Nora Eccles Harrison Cardiovascular Research and Training Institute (October 1990).
Tel-Aviv University, Israel, Department of Physics and Astronomy (June - July, 1991).
Columbia University, College of Physicians and Surgeons, Department of Pharmacology, New York, August 1994.
Cornell University, Department of Physiology, Ithaca, New York, October 1994.
Masonic Medical Research Laboratory, Utica, New York, December 1995.
Russian Academy of Sciences, St. Petersburg, June 1997.

Selected Publications

C. Luo and Y. Rudy, "A Dynamic Model of the Cardiac Ventricular Action Potential: I. Simulations of Ionic Currents and Concentration Changes” Circulation Research 1994; 74: 1071-1096.
C. E. Clancy, Y. Rudy, "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia" Nature 1999;400:566-569.
C.E. Clancy, Y. Rudy, “A Na+ Channel Mutation that Causes Both Brugada and Long QT Syndrome Phenotypes: A Simulation Study of Mechanism” Circulation 2002;105:1208-1213.
R.M. Shaw and Y. Rudy, "Electrophysiologic Effects of Acute Myocardial Ischemia: A Theoretical Study of Altered Cell Excitability and Action Potential Duration" Cardiovascular Research 1997; 35: 256-272
P.C. Viswanathan, R.M. Shaw, Y. Rudy, "Effects of Ikr and Iks Heterogeneity on Action Potential Duration and its Rate - Dependence: A Simulation Study" Circulation 1999; 99:2466-2474.
J. Zeng and Y. Rudy, "Early Afterdepolarizations in Cardiac Myocytes: Mechanism and Rate Dependence” Biophys J 1995; 68: 949-964.
G.M. Faber, Y. Rudy, “Action Potential and Contractility Changes in [Na+]i Overloaded Cardiac Myocytes: A Simulation Study” Biophys J 2000; 78:2392-2404.
W. Quan and Y. Rudy, "Unidirectional Block and Reentry of Cardiac Excitation–A Model Study” Circulation Research 1990; 66: 367-382.
R.M. Shaw and Y. Rudy, "Elecrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure" Circ Res 1997 ; 80:124-138.
R.M. Shaw and Y. Rudy, “Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-Type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling” Circ Res 1997; 81:727-741.
Y. Wang, Y. Rudy, "Action Potential Propagation in Inhomogeneous Cardiac Tissue: Safety Factor Considerations and Ionic Mechanism" Am J Physiol (Heart) 2000;278:H1019-H1029.
T. J. Hund, N.F. Otani, Y. Rudy, “The Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Ionic Mechanisms” Am J Physiol (Heart) 2000; 279:H1869-H1879.
J.P. Kucera, Y. Rudy, “Mechanistic Insights into Very Slow Conduction in Branching Cardiac Tissue: A Model Study” Circ Res 2001; 89:799-806.
J.P. Kucera, S. Rohr, Y. Rudy, “Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction” Circulation Research 2002; 91:1176-1182.
A.G. Kleber, Y. Rudy, “Basic Mechanisms of Cardiac Impulse Propagation and Reentrant Arrhythmias” Physiological Reviews 2004 (in press)
C. Ramanathan, R.N. Ghanem, P. Jia, K. Ryu, Y. Rudy, “Electrocardiographic Imaging (ECGI): A Noninvasive Imaging Modality for Cardiac Electrophysiology and Arrhythmia” Nature Medicine 2004 (in press)
K. Gima, Y. Rudy, “ Ionic Current Basis of Electrocardiographic Waveforms: A Model Study “ Circulation Research 2002;90:889-896.
H.S.Oster, B.Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy, "Noninvasive Electrocardiographic Imaging: Reconstruction of Epicardial Potentials, Electrograms and Isochrones, and Localization of Single and Multiple Electrocardiac Events" Circulation 1997; 96: 1012-1024.
H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy, “Electrocardiographic Imaging: Noninvasive Characterization of Intramural Myocardial Activation from Inverse Reconstructed Epicardial Potentials and Electrograms” Circulation 1998; 97:1496-1507.
J.E. Burnes, B. Taccardi, R.S. MacLeod, Y. Rudy, "Noninvasive Electrocardiographic Imaging of Electrophysiologically Abnormal Substrate in Infarcted Hearts: A Model Study" Circulation 2000;101:533-540.
J. E. Burnes, B. Taccardi, Y. Rudy, “A Noninvasive Imaging Modality for Cardiac Arrhythmias” Circulation 2000; 102:2152-2158.
J. E. Burnes, B. Taccardi, P. Ershler, Y. Rudy, “Noninvasive ECG Imaging of Substrate and Intramural Ventricular Tachycardia in Infarcted Hearts” J Amer College Cardiol (JACC) 2001;38:2071-2078.
R.N. Ghanem, J.E. Burnes A.L. Waldo, Y. Rudy, “ Electrocardiographic Imaging: Noninvasive Reconstruction of Epicardial Measures of Dispersion of Repolarization” Biomedizinische Technik 2001;46:201-203.
C. Ramanathan, Y. Rudy, “Electrocardiographic Imaging:II. Effect of Torso Inhomogeneities on the Noninvasive Reconstruction of Epicardial Potentials, Electrograms and Isochrones” J Cardiovasc Electrophysiol 2001; 12:241-252.
C. Ramanathan, P. Jia, R.N. Ghanem, D. Calvetti, Y. Rudy, “Noninvasive Electrocardiographic Imaging (ECGI): Application of the Generalized Minimal Residual (GMRes) Method” Annals of Biomedical Engineering 2003; 31:981-994.
P. Jia, B.Punske, B.Taccardi, Y. Rudy, “Endocardial Mapping of Electrophysiologically Abnormal Substrates and Cardiac Arrhythmias using a Noncontact Nonexpandable Catheter” J Cardiovasc Electrophysiol 2002;13:888-895.

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