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Yoram Rudy
 Current Position at Washington University
in St. Louis
| The Fred Saigh Distinguished Professor of Biomedical Engineering |
| Director, Cardiac Bioelectricity and Arrhythmia Center (CBAC) |
| Professor of Cell Biology & Physiology, Medicine, Pediatrics, and Radiology |
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Previous Position at Case Western Reserve
University
| The M. Frank and Margaret C. Rudy Professor of Cardiac Bioelectricity |
| Director, Cardiac Bioelectricity Research and Training Center (CBRTC) |
| Professor of Biomedical Engineering, Physiology and Biophysics, and Medicine |
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Education
| Technion, Haifa, Israel, B.Sc., 1971, Physics |
| Technion, Haifa, Israel, M.Sc., 1973, Physics |
| Case Western Reserve University, School of Medicine, 1 year, 1976 |
| Case Western Reserve University, Ph.D., 1978, Biomedical Engineering |
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Honors and Awards
Member of the National Academy of Engineering
Citation: “For leadership in the engineering sciences of cardiac excitation at the genetic and molecular levels and for introducing new methods in clinical diagnosis and therapy” |
| NIH MERIT Award, September, 1998 |
| The Biomedical Engineering Society (BMES) 2001 Distinguished Lectureship Award |
Fellow of the American Physiological Society
Citation: "For outstanding research contributions in the field of cardiac electrophysiology" |
Fellow of the Institute of Electrical and Electronics Engineers (IEEE)
Citation: "For contributions to mathematical descriptions and solutions applicable to cardiac electrophysiology" |
Fellow of the American Institute of Medical and Biological Engineering (AIMBE)
Citation: "In recognition of outstanding contributions to the field of medical and biological engineering" |
The Gordon K Moe Professorship Award, Masonic Medical Research Laboratory, 1997.
Citation: “In recognition of outstanding contributions to science and medicine in the fields of cardiac electrophysiology and arrhythmias” |
| The A.C. Suhren Jr. Scholar, Tulane University, 1998. |
| Keynote Address, Biomedical Engineering Day, Washington University in St. Louis, March, 2001. |
The Rijlant Distinguished Lecturer, International Congress on Electrocardiology, Milan,
Italy, 2000. |
The Ueda Memorial Lecture Award, The Japanese Society of Electrocardiology and
Japan College of Cardiology, Nagoya, Japan, September 2002. |
| Sigma Xi |
| Who's Who in America |
| Who's Who in Science and Engineering |
| Who's Who in the World |
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Visiting Professorships
| Technion - Israel Institute of Technology, Haifa, Israel, Department of Biomedical Engineering (Dec. 1982 - Mar. 1983). |
| University of Parma, Italy, Institute of General Physiology (July 1986 and July 1987). |
| University of Berne, Switzerland, Department of Physiology (May 1990). |
| University of Utah, Salt Lake City, The Nora Eccles Harrison Cardiovascular Research and Training Institute (October 1990). |
| Tel-Aviv University, Israel, Department of Physics and Astronomy (June - July, 1991). |
| Columbia University, College of Physicians and Surgeons, Department of Pharmacology, New York, August 1994. |
| Cornell University, Department of Physiology, Ithaca, New York, October 1994. |
| Masonic Medical Research Laboratory, Utica, New York, December 1995. |
| Russian Academy of Sciences, St. Petersburg, June 1997. |
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Selected Publications
| C. Luo and Y. Rudy, "A Dynamic Model of the Cardiac Ventricular Action Potential: I. Simulations of Ionic Currents and Concentration Changes” Circulation Research 1994; 74: 1071-1096. |
| C. E. Clancy, Y. Rudy, "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia" Nature 1999;400:566-569. |
| C.E. Clancy, Y. Rudy, “A Na+ Channel Mutation that Causes Both Brugada and Long QT Syndrome Phenotypes: A Simulation Study of Mechanism” Circulation 2002;105:1208-1213. |
| R.M. Shaw and Y. Rudy, "Electrophysiologic Effects of Acute Myocardial Ischemia: A Theoretical Study of Altered Cell Excitability and Action Potential Duration" Cardiovascular Research 1997; 35: 256-272 |
| P.C. Viswanathan, R.M. Shaw, Y. Rudy, "Effects of Ikr and Iks Heterogeneity on Action Potential Duration and its Rate - Dependence: A Simulation Study" Circulation 1999; 99:2466-2474. |
| J. Zeng and Y. Rudy, "Early Afterdepolarizations in Cardiac Myocytes: Mechanism and Rate Dependence” Biophys J 1995; 68: 949-964. |
| G.M. Faber, Y. Rudy, “Action Potential and Contractility Changes in [Na+]i Overloaded Cardiac Myocytes: A Simulation Study” Biophys J 2000; 78:2392-2404. |
| W. Quan and Y. Rudy, "Unidirectional Block and Reentry of Cardiac Excitation–A Model Study” Circulation Research 1990; 66: 367-382. |
| R.M. Shaw and Y. Rudy, "Elecrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure" Circ Res 1997 ; 80:124-138. |
| R.M. Shaw and Y. Rudy, “Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-Type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling” Circ Res 1997; 81:727-741. |
| Y. Wang, Y. Rudy, "Action Potential Propagation in Inhomogeneous Cardiac Tissue: Safety Factor Considerations and Ionic Mechanism" Am J Physiol (Heart) 2000;278:H1019-H1029. |
| T. J. Hund, N.F. Otani, Y. Rudy, “The Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Ionic Mechanisms” Am J Physiol (Heart) 2000; 279:H1869-H1879. |
| J.P. Kucera, Y. Rudy, “Mechanistic Insights into Very Slow Conduction in Branching Cardiac Tissue: A Model Study” Circ Res 2001; 89:799-806. |
| J.P. Kucera, S. Rohr, Y. Rudy, “Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction” Circulation Research 2002; 91:1176-1182. |
| A.G. Kleber, Y. Rudy, “Basic Mechanisms of Cardiac Impulse Propagation and Reentrant Arrhythmias” Physiological Reviews 2004 (in press) |
| C. Ramanathan, R.N. Ghanem, P. Jia, K. Ryu, Y. Rudy, “Electrocardiographic Imaging (ECGI): A Noninvasive Imaging Modality for Cardiac Electrophysiology and Arrhythmia” Nature Medicine 2004 (in press) |
| K. Gima, Y. Rudy, “ Ionic Current Basis of Electrocardiographic Waveforms: A Model Study “ Circulation Research 2002;90:889-896. |
| H.S.Oster, B.Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy, "Noninvasive Electrocardiographic Imaging: Reconstruction of Epicardial Potentials, Electrograms and Isochrones, and Localization of Single and Multiple Electrocardiac Events" Circulation 1997; 96: 1012-1024. |
| H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy, “Electrocardiographic Imaging: Noninvasive Characterization of Intramural Myocardial Activation from Inverse Reconstructed Epicardial Potentials and Electrograms” Circulation 1998; 97:1496-1507. |
| J.E. Burnes, B. Taccardi, R.S. MacLeod, Y. Rudy, "Noninvasive Electrocardiographic Imaging of Electrophysiologically Abnormal Substrate in Infarcted Hearts: A Model Study" Circulation 2000;101:533-540. |
| J. E. Burnes, B. Taccardi, Y. Rudy, “A Noninvasive Imaging Modality for Cardiac Arrhythmias” Circulation 2000; 102:2152-2158. |
| J. E. Burnes, B. Taccardi, P. Ershler, Y. Rudy, “Noninvasive ECG Imaging of Substrate and Intramural Ventricular Tachycardia in Infarcted Hearts” J Amer College Cardiol (JACC) 2001;38:2071-2078. |
| R.N. Ghanem, J.E. Burnes A.L. Waldo, Y. Rudy, “ Electrocardiographic Imaging: Noninvasive Reconstruction of Epicardial Measures of Dispersion of Repolarization” Biomedizinische Technik 2001;46:201-203. |
| C. Ramanathan, Y. Rudy, “Electrocardiographic Imaging:II. Effect of Torso Inhomogeneities on the Noninvasive Reconstruction of Epicardial Potentials, Electrograms and Isochrones” J Cardiovasc Electrophysiol 2001; 12:241-252. |
| C. Ramanathan, P. Jia, R.N. Ghanem, D. Calvetti, Y. Rudy, “Noninvasive Electrocardiographic Imaging (ECGI): Application of the Generalized Minimal Residual (GMRes) Method” Annals of Biomedical Engineering 2003; 31:981-994. |
| P. Jia, B.Punske, B.Taccardi, Y. Rudy, “Endocardial Mapping of Electrophysiologically Abnormal Substrates and Cardiac Arrhythmias using a Noncontact Nonexpandable Catheter” J Cardiovasc Electrophysiol 2002;13:888-895. |
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