Rudy Lab Cardiac Excitation & Arrhythmia Publications
Publications | Cardiac Excitation & Arrhythmia | ECGI

Cardiac Excitation & Arrhythmia Publications in Refereed Journals

2014-Present | 2012-2013 | 2010-2011 | 2007-2009 | 2005-2006 | 2002-2004 | 2000-2001 | 1997-1999 | 1993-1996
| 1978-1988

2014 - Present

A. Nekouzadeh, Y. Rudy. "Conformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1." Prog Biophys Mol Biol. 2016 Jan;120(1-3):18-27. 2015.12.014. Epub 2015 Dec 30. PMCID: PMC4955398.

H.C. Lee,Y. Rudy, H. Liang, C.C. Chen, C.H. Luo, S.H. Sheu, J. Cui. "Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets - Insights from Modeling." J Med Biol Eng. 2017 Oct;37(5):780-789. PMCID: PMC5714284

S. Ramasubramanian, Y. Rudy. "The Structural Basis of IKs Ion-Channel Activation: Mechanistic Insights from Molecular Simulations." Biophys J. 2018 Jun;114(11):2584-2594. doi: 10.1016/j.bpj.2018.04.023. PMCID: PMC6129186

J. Xu, Y. Rudy. "Effects of β-subunit on gating of a potassium ion channel: Molecular simulations of cardiac IKs activation." J Mol Cell Cardiol. 2018 Nov;124:35-44. doi: 10.1016/j.yjmcc.2018.10.003. Epub 2018 Oct 4. PMCID:PMC6265052


2012 - 2014

L. Livshitz, K. Acsai, G. Antoons, K. Sipido, Y. Rudy, "Data-Based Theoretical Identification of Subcellular Calcium Compartments and Estimation of Calcium Dynamics in Cardiac Myocytes". J Physiol. 2012 Sep 15;590(Pt 18):4423-46. doi: 10.1113/jphysiol.2012.228791. Epub 2012 Apr 30. PMCID: PMC3477750

T. O’Hara, Y. Rudy,Quantitative Comparison of Cardiac Ventricular Myocyte  Electrophysiology and Response to Drugs in Human and Non-Human Species”  Am J Physiol Heart Circ Physiol 2012;302: H1023–H1030. PMCID: PMC3311457

D. Jeyaraj, X. Wan, E. Ficker, J. E. Stelzer, I. Deschenes, H. Liu, L. Wilson, K. Decker, T. Said, M. Jain, Y. Rudy, D. Rosenbaum, "Ionic bases for electrical remodeling of the  canine cardiac ventricle"  Am J Physiol Heart Circ Physiol August 2013; Volume 305 no. H410-H419DOI: 10.1152/ajpheart.00213.2013. Epub 2013 May 24. PMCID: MC3742876.

J. Heijman, A. Zaza, D.M. Johnson, Y. Rudy, R.L.M. Peeters, P.G.A. Volders, R.L. Westra,“Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: a Computational AnalysisPLoS Computational  Biology, August 2013; Volume 9, Issue 8, e1003202. Epub 2013 Aug 22. PMCID: PMC3749940.

H.C. Lee, Y. Rudy, P.Y. Chen, S.H. Sheu,  J.G. Chang,  J. Cui,  “Modulation of KCNQ1 Alternative Splicing Regulates Cardiac IKs Currents and Action Potential Repolarization”  Heart Rhythm 2013;10:1220-1228. doi: 10.1016/j.hrthm.2013.04.014. Epub 2013 Apr 19. PMCID: PMC3771516.

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D. Wu, K. Delaloye, M. Zaydman, A. Nekouzadeh, ,Y. Rudy, J. Cui, "State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation" J. Gen. Physiol. 2010 Jun;135(6):595-606. doi: 10.1085/jgp.201010408. Epub 2010 May 17. PMCID: PMC2888051

J. R. Silva, Y. Rudy, "Multi-scale electrophysiology modeling: from atom to organ" J. Gen. Physiol. 2010;135:575-581. PMCID: PMC2888060

K.F. Decker, Y. Rudy, "Ionic Mechanisms of Electrophysiological Heterogeneity and Conduction Block in the Infarct Border Zone"Am J Physiol Heart Circ Physiol 2010; 299: H1588–H1597. PMCID: PMC2993197

J. Heijman, P.G.A. Volders, R.L. Westra, Y. Rudy, “Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient” J Mol Cell Cardiol 2011;50:863-871. PMCID: PMC3075371

K. Acsai, G. Antoons, L. Livshitz, Y. Rudy, K. R. Sipido, “Microdomain [Ca2+] near ryanodine receptors as reported by L-type Ca2+ and Na/Ca exchange currentsJ Phsiol 2011;589:2569-2583. PMCID: PMC3115826

A. Nekouzadeh, Y. Rudy, Three Residue Loop Closure in Proteins:  A New Kinematic Method Reveals a Locus of Connected Loop Conformations
J Comp Chemistry 2011; 32: 2515–2525. PMCID: PMC4154380

A. Nekouzadeh, Y. Rudy, “Continuum Molecular Simulation of Large Conformational Changes during Ion-Channel GatingPLoS ONE 2011; 6(5): e20186. doi:10.1371/journal.pone.0020186. PMCID: PMC3098872

T.J. O’Hara, L. Virág, A. Varró, Y. Rudy, “Simulation of the undiseased human cardiac  ventricular action potential: Model formulation and experimental validationPLoS Computational Biology 2011; 7(5): e1002061.doi:10.1371/journal.pcbi.1002061. PMCID: PMC3102752

P. Li, Y. Rudy,A Model of Canine Purkinje Cell Electrophysiology and Ca2+ Cycling: Rate Dependence, Triggered Activity and Comparison to Ventricular MyocyteCirc Res 2011; 109:71-79 (Issue Highlight). PMCID: PMC3143030

N. Gaur, Y. Rudy, “Multiscale modeling of Ca cycling in cardiac ventricular myocyte:   Macroscopic consequences of microscopic dyadic functionBiophys J 2011; 100:2904-2912. PMCID: PMC3123916

T. O’Hara, Y. Rudy,Arrhythmia Formation in Subclinical (“Silent”) Long QT Syndrome  Requires Multiple Insults: Quantitative Mechanistic Study Using the KCNQ1 Mutation Q357R as Example”  Heart Rhythm 2011;9:275-282. PMCID: PMC3443981

T. O’Hara, Y. Rudy,Quantitative Comparison of Cardiac Ventricular Myocyte  Electrophysiology and Response to Drugs in Human and Non-Human Species”  Am J Physiol Heart Circ Physiol 2012;302: H1023–H1030. PMCID: PMC3311457

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C. Clancy, Z.I. Zhu, Y. Rudy, “Pharmacogenetics and Anti-arrhythmic Drug Therapy: A Theoretical Investigation Am J Physiol 2007; 292: H66-H75. PMCID: PMC2034498

G.M. Faber, J. Silva, L. Livshitz, Y. Rudy, “Kinetic Properties of the Cardiac L-type Ca2+ Channel and its Role in Myocyte Electrophysiology: A Theoretical InvestigationBiophys J 2007; 92:1522-1543. PMCID: PMC1796810.

L. Livshitz, Y. Rudy, “Regulation of Ca2+ and Electrical Alternans in Cardiac Myocytes: Role of CaMKII and Repolarizing CurrentsAm J Physiol 2007; 292:H2854-H2866. PMCID: PMC2274911.

A. Nekouzadeh, Y. Rudy, “Statistical Properties of Ion Channel records: I. Relationship to the Macroscopic Current”, Mathematical Biosciences 2007;210:291-314. PMCID: PMC2121577.

A. Nekouzadeh, Y. Rudy, “Statistical Properties of Ion Channel records: II. Estimation from the Macroscopic Current”, Mathematical Biosciences 2007;210:315-334.
PMCID: PMC2151058.

G. Faber, Y. Rudy, “Calsequestrin Mutation and Catecholaminergic Polymorphic Ventricular Tachycardia: A Simulation Study of Cellular Mechanism”, Cardiovascular Research 2007; 75:79-88. PMCID: PMC2030636.

Y. Rudy
, “Modeling the Molecular Basis of Cardiac Repolarization”, Europace 2007; 9: vi17-vi19. PMID: 17959688

Y. Rudy
, “Molecular Basis of Cardiac Action Potential Repolarization”, Annals of the New York  Academy of Sciences 2008; 1123:113-118. PMID: 18375583

M. Bebarova, T. O’Hara, J.L.M.C. Geelen, R.J. Jongbloed, C. Timmermans, Y.H. Arens, L.M. Rodriguez, Y. Rudy, P.G. Volders, “Subepicardial phase-0 block and discontinuous transmural conduction underlie right-precordial ST-segment elevation by a SCN5A loss-of-function mutation”, Am J Physiol Heart Circ Physiol 2008;295:H48-H58. PMCID: PMC2494753

T.J. Hund, K.F. Decker, E. Kanter, P.J. Mohler, P.A. Boyden, R.B. Schuessler, K.A. Yamada, Y. Rudy, “Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling”, J of Molecular and Cellular Cardiology 2008;45:420-428. PMCID: PMC2587155

A. Nekouzadeh, J. Silva, Y. Rudy, “Modeling subunit cooperativity in opening of tetrameric ion channelsBiophysical Journal 2008;95:3510-3520. PMCID: PMC2547442

Y. Rudy,
M.J. Ackerman, D. M. Bers, C. E. Clancy, S. R. Houser, B. London, A. D. McCulloch, D. A. Przywara, R. L. Rasmusson, R. J. Solaro, N. A. Trayanova, D. R. Van Wagoner, A. Varró, J. N. Weiss, D. A. Lathrop, “Systems Approach to Understanding Electromechanical Activity in the Human HeartCirculation 2008;118:1202-1211. PMCID: PMC2908516

H Sale, J Yang, TJ O’Hara, DJ Tester, P Phartiyal, JQ He, Y Rudy, MJ Ackerman, GA Robertson, “Physiological properties of hERG 1a/1b heteromeric currents and hERG 1b-specific mutation associated with long-QT syndromeCirc Res 2008; 103:e81-e95. PMCID: PMC2761010

M Haissaguerre, JJ Schott, F Sacher, G Lousouran, R Weerasooriya, V Probst, M Horlitz, R Liersch, S LeScouarnec, M Hocini, P Bordachar, P Jais, A Wilde, C Nichols, Y Rudy, H LeMarec “Ventricular fibrillation with prominent early repolarization changes associated to KCNJ8/KATP channel mutation J Cardiovasc Electrophysiol 2009;20:93-98. PMID: 19120683

K. F. Decker, J. Heijman, J.R. Silva, T. J. Hund, Y. Rudy, "Properties and Ionic Mechanisms of Action Potential Adaptation, Restitution and Accommodation in Canine Epicardium" Am J Physiol Heart Circ Physiol 2009; 296:1017-1026. PMCID: PMC2670702

J. R. Silva, H. Pan, D. Wu, A. Nekouzadeh, K. Decker, J. Cui, N. A. Baker, D. Sept, Y. Rudy, “A Multiscale Model Linking Ion-Channel Molecular Dynamics and Electrostatics to the Cardiac Action PotentialProc Natl Acad Sci USA (PNAS) 2009;106:11102-11106. PMCID: PMC2700153

L. Livshitz, Y. Rudy, "Uniqueness and Stability of Action Potential Models during Rest, Pacing, and Conduction Using Problem-Solving Environment" Biophysical Journal 2009;97:1265-1276. PMCID: PMC2749757

N. Gaur, Y. Rudy, L. Hool, "Contributions of ion-channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia" Circulation Research 2009;105:1196-1203. PMCID: PMC2826175

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Y. Rudy
, “Lessons Learned about Slow Discontinuous Conduction from Models of Impulse PropagationJ Electrocardiol 2005;38:52-54. PMID: 16226074

J. Silva, Y. Rudy, “Subunit Interaction Determines IKs Participation in Cardiac Repolarization and Repolarization reserveCirculation 2005;112:1384-1391. PMCID: PMC1820744

L. Livshitz, K. Decker, G. Faber, T. O’Hara, J. Silva, Y. Rudy , “Comments on a Model for Human Ventricular TissueAm J Physiol Heart Circ Physiol 2005;288:H453- H454 (letter). PMID: 15598875

Y. Rudy
, “Modeling and Imaging Cardiac Repolarization AbnormalitiesJournal of Internal Medicine 2006;259:91-106. PMCID: PMC1865512

Y. Rudy
, J.R. Silva, "Computational Biology in the Study of Cardiac Ion Channels and Cell Electrophysiology" Quarterly Reviews of Biophysics 2006; 39:57-116. PMCID: PMC1994938

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C.E. Clancy, Y. Rudy , "A Na+ Channel Mutation that Causes Both Brugada and Long QT Syndrome Phenotypes: A Simulation Study of Mechanism" Circulation 2002;105:1208-1213. PMCID: PMC1997279

J.P. Kucera, S. Rohr, Y. Rudy , "Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction" Circulation Research 2002; 91:1176-1182. PMCID: PMC1888562

K. Gima, Y. Rudy , "Ionic Current Basis of Electrocardiographic Waveforms: A Model Study" Circulation Research 2002;90:889-896. PMCID: PMC1847799

J.P. Kucera, S. Rohr, Y. Rudy, “Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction”  Circulation Research 2002; 91:1176-1182. PMCID: PMC1888562

J. Silva, Y. Rudy , "Pacemaking Activity in Ventricular Myocytes Under Downregulation of Ik1: A Study of Mechanism" Circulation Research 2003; 92:261-263. PMCID: PMC1890031

S.P. Thomas, J.P. Kucera, L. Bircher-Lehman, Y. Rudy , J.E. Saffitz, A.G. Kleber, "Impulse Propagation in Synthetic Strands of Neonatal Cardiac Myocytes with Genetically Reduced Levels of Connexin43" Circulation Research 2003; 92:1209-1216. PMCID: PMC2242733  

T. O’Hara, K. Decker, G. Faber, L. Livshitz, J. Silva, Y. Rudy , “Comments on: Role of Individual Ionic Current Systems in Ventricular Cells Hypothesized by Model Study Jpn J Physiol 2004;54:505-508 (letter). PMID: 15667675

T.J. Hund, Y. Rudy, "Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model" Circulation 2004; 110:3168-3174. PMCID: PMC1851913  

Y. Rudy
, “From Genetics to Cellular Function Using Computational BiologyAnnals N.Y. Academy of Science 2004; 1015:261-270. PMID: 15201166

A.G. Kleber, Y. Rudy , "Basic Mechanisms of Cardiac Impulse Propagation and Reentrant Arrhythmias" Physiological Reviews 2004; 84:431-488. PMID: 15044680

Y. Rudy, “Genetic Defects, Ionic Currents and Electrocardiographic Alterations” Annals of Medicine 2004; 36:15-21. PMID: 15176419

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T. J. Hund, Y. Rudy "Determinants of Excitability in Cardiac Myocytes: Mechanistic Investigation of Memory Effect" Biophys J 2000; 79:3095-3104. PMCID: PMC1301186

E. Ficker, D. Thomas, P.C. Viswanathan, A. T. Dennis, S. G. Priori, C. Napolitano, M. Memmi, B.A. Wible, E. S. Kaufman, S. Iyengar, P. J. Schwartz, Y. Rudy , A.M. Brown, "Novel Characteristics of a Misprocessed Mutant HERG Channel Linked to Hereditary Long QT Syndrome" Am J Physiol (Heart) 2000; 279:H1748-H1756. PMID: 11009462

T. J. Hund, N.F. Otani, Y. Rudy , "The Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Ionic Mechanisms" Am J Physiol (Heart) 2000; 279:H1869-H1879. PMID: 11009475

Y. Rudy
, "From Genome to Physiome: Integrative Models of Cardiac Excitation" Annals of Biomedical Engineering 2000; 28:945-950. PMID: 11144679

G.M. Faber, Y. Rudy , "Action Potential and Contractility Changes in [Na+]i Overloaded Cardiac Myocytes: A Simulation Study" Biophys J 2000; 78:2392-2404. PMCID: PMC1300828

Y. Wang, Y. Rudy , "Action Potential Propagation in Inhomogeneous Cardiac Tissue: Safety Factor Considerations and Ionic Mechanism" Am J Physiol (Heart) 2000;278:H1019- H1029. PMID: 10749693

P.C. Viswanathan, Y. Rudy , "Cellular Arrhythmogenic Effects of the Congenital and Acquired Long QT Syndrome in the Heterogeneous Myocardium" Circulation 2000;101:1192- 1198. PMID: 10715268

Y. Rudy
, "The Ionic Mechanisms of Conduction in Cardiac Tissue" J Electrocardiology 2001 ; 34:65-68. PMID: 11781938

Y. Rudy
together with other 23 members of the Sicilian Gambit on Cardiac Arrhythmia, "New Approaches to Antiarrhythmic Therapy: Emerging Therapeutic Applications of the Cell Biology of Cardiac Arrhythmias", Part I, Circulation 2001;104:2865-2873. Co-Published in European Heart Journal, and Cardiovascular Research. PMID: 11733408

Y. Rudy together with other 23 members of the Sicilian Gambit on Cardiac Arrhythmia, "New Approaches to Antiarrhythmic Therapy: Emerging Therapeutic Applications of the Cell Biology of Cardiac Arrhythmias", Part II, Circulation 2001;104:2990-2994. Co-Published in European Heart Journal, and Cardiovascular Research. PMID: 11739317

J.P. Kucera, Y. Rudy , "Mechanistic Insights into Very Slow Conduction in Branching Cardiac Tissue: A Model Study" Circ Res 2001; 89:799-806. PMID: 11679410

T.J. Hund, J.P. Kucera, N.F. Otani, Y. Rudy , "Ionic Charge Conservation and Long - Term Steady State in the Luo-Rudy Dynamic Cell Model" Biophys J 2001;81:3324-3331. PMCID: PMC1301789

D. Nuyens, M. Stengl, S. Dugarmaa, T. Rossenbacker, V. Compernolle, Y. Rudy , J.F. Smits, W. Flameng, C.E. Clancy, L. Moons, M.A. Vos, M. Dewerchin, K. Benndorf, D. Collen, E. Carmeliet, P. Carmeliet, "Abrupt Rate Accelerations or Premature Beats Cause Life Threatening Arrhythmias in Mice with Long-QT3 Syndrome" Nature Medicine 2001; 7:1021-1027. PMID: 11533705

D. Noble, Y. Rudy , "Models of Cardiac Ventricular Action Potentials: Iterative Interaction Between Experiment and Simulation" Philosophical Transactions Royal Society (London) 2001; 359:1127-1142.

C. E. Clancy, Y. Rudy , "Cellular Consequences of HERG Mutations in the Long QT Syndrome: Precursors to Sudden Cardiac Death" Cardiovascular Research 2001 ;50:301-313. PMID: 11334834

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R.M. Shaw and Y. Rudy , "Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-Type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling" Circ Res 1997; 81:727-741. PMID: 9351447

Y. Rudy
and R.M. Shaw, "Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions" Adv Exp Med Biol 1997; 430: 269-280. PMID: 9330736

K.R. Laurita, S.D. Girouard, Y. Rudy , D.S. Rosenbaum, "Role of Passive Electrical Properties During Action Potential Restitution in the Intact Heart" Am J. Physiol 1997; 273: H1205-H1214. PMID: 9321808

R.M. Shaw and Y. Rudy , "Electrophysiologic Effects of Acute Myocardial Ischemia: A Theoretical Study of Altered Cell Excitability and Action Potential Duration" Cardiovascular Research 1997; 35: 256-272. PMID: 9349389

R.M. Shaw and Y. Rudy , "Elecrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure" Circ Res 1997 ; 80:124-138. PMID: 8978331

C. E. Clancy, Y. Rudy , "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia" Nature 1999;400:566-569. PMID: 10448858

P.C. Viswanathan, Y. Rudy , "Pause Induced Early Afterdepolarizations in the Long QT Syndrome: A Simulation Study" Cardiovascular Research 1999; 42:530-542. PMID: 10533588

P.C. Viswanathan, R.M. Shaw, Y. Rudy , "Effects of Ikr and Iks Heterogeneity on Action Potential Duration and its Rate - Dependence: A Simulation Study" Circulation 1999; 99:2466-2474. PMID: 10318671

Y. Rudy, "Cardiac Conduction: An Interplay Between Membrane and Gap Junction" J Electrocardiology 1999; 31:1-5. PMID: 9987998

S.G. Priori, J. Barhanin, R.N.W. Hauer, W. Haverkamp, H.J. Jongsma, A.G. Kleber, W.J. McKenna, D.M. Roden, Y. Rudy , K. Schwartz, P.J. Schwartz, J.A. Towbin, A.M. Wilde, "Genetic and Molecular Basis of Cardiac Arrhythmias, Parts I and II" Circulation 1999; 99:518-528. (Also published in Eur Heart J. 1999;20:179-195). PMID: 9927398

S.G. Priori, J. Barhanin, R.N.W. Hauer, W. Haverkamp, H.J. Jongsma, A.G. Kleber, W.J. McKenna, D.M. Roden, Y. Rudy , K. Schwartz, P.J. Schwartz, J.A. Towbin, A.M. Wilde, "Genetic and Molecular Basis of Cardiac Arrhythmias, Part III" Circulation 1999; 99:674-681. (Also published in Eur Heart J. 1999; 20:179-195). PMID: 9950666

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Y. Rudy
and C. Luo, "Cellular Responses to Electrical Stimulation-A Study Using a Model of the Ventricular Cardiac Action Potential" Adv Exp Med Biol 1993; 346: 79-90. PMID: 8184783

J. Ortiz, M. Igarashi, H.X. Gonzalez, K. Laurita, Y. Rudy , and A.L. Waldo, "Mechanism of Spontaneous Termination of Stable Atrial Flutter in the Canine Sterile Pericarditis Model" Circulation 1993; 88: 1866-1877. PMID: 8403332

A. Shimizu, A. Nozaki, Y. Rudy , and A.L. Waldo, "Characterization of Double Potentials in a Functionally Determined Reentrant Circuit" J Amer Coll Cardiol 1993; 22: 2022- 2032. PMID: 8245362

S. Niwano, J.Ortiz, H. Abe, X. Gonzalez, Y. Rudy , and A.L. Waldo, "Characterization of the excitable gap in a functionally determined reentrant circuit" Circulation 1994; 90: 1997-2014. PMID: 7522990

J. Ortiz, A. Nozaki, A. Shimizu, Y. Rudy , and A.Waldo, "Mechanism of Interruption of Atrial Flutter by Moricizine: Electrophysiological and Multiplexing Studies in the Canine Sterile Pericarditis Model of Atrial Flutter" Circulation 1994; 89: 2860-2869. PMID: 8205702

D.W. Whalley, D.J. Wendt, C.F. Starmer, Y. Rudy , and A.O. Grant, "Voltage- Independent Effects of Extracellular K+ on the Na+ Current and Phase 0 of the Action Potential in Isolated Cardiac Myocytes" Circulation Research 1994; 75: 491-502. PMID: 8062422

C. Luo and Y. Rudy , "A Dynamic Model of the Cardiac Ventricular Action Potential: I. Simulations of Ionic Currents and Concentration Changes" Circulation Research 1994; 74: 1071-1096. PMID: 7514509

C. Luo and Y. Rudy , "A Dynamic Model of the Cardiac Ventricular Action Potential: II. Afterdepolarizations, Triggered Activity and Potentiation" Circulation Research 1994; 74: 1097-1113. PMID: 7514510

F. Dexter, Y. Rudy , and G.M. Saidel, "Mathematical Model of Acetylcholine Kinetics in Neuroeffector Junctions" Am J Physiol 1994; 266 (Heart Circ. Physiol 35): H298- H309. PMID: 8304512

Y. Rudy
, "Model Studies of Cellular Excitation" Adv Exp Med Biol 1995; 382: 67-77. PMID: 8540415

J. Zeng, K. R. Laurita, D. S. Rosenbaum, and Y. Rudy, "Two Components of the Delayed Rectifier K+ Current in Ventricular Myocytes of the Guinea Pig Type: Theoretical Formulation and their Role in Repolarization" Circulation Research 1995; 77: 1-13. PMID: 7788872

Y. Rudy
, "Reentry: Insights from Theoretical Simulations in a Fixed Pathway" J Cardiovascular Electrophysiology 1995; 6: 294-312. PMID: 7544193

R.M. Shaw and Y. Rudy , "The Vulnerable Window for Unidirectional Block in Cardiac Tissue: Characterization and Dependence on Membrane Excitability and Cellular Coupling" J Cardiovascular Electrophysiology 1995; 6: 115-131. PMID: 7780627

J. Zeng and Y. Rudy , "Early Afterdepolarizations in Cardiac Myocytes: Mechanism and Rate Dependence" Biophys J 1995; 68: 949-964. PMCID: PMC1281819

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F. Dexter, G.M. Saidel, and Y. Rudy , "Simulation of the diffusion of Acetylcholine in the Neuroeffector Junctions of the Sinus Node" J Theo Boils 1989; 141: 505-514. PMID: 2630802

F. Dexter, M.N. Levy, Y. Rudy , "Mathematical Model of the Changes in Heart Rate Elicited by Vagal Stimulation" Circulation Research 1989; 65: 1330-1339. PMID: 2805246

F. Dexter, Y. Rudy , M.N. Levy, "Muscarinic Autoreceptors do not Modulate Kinetics of Acetylcholine Release in Hearts" Am J Physiol 1989; 256 (Heart Circ Physiol 25): H1073-H1078. PMID: 2705550

F. Dexter, G.M. Saidel, M.N. Levy, and Y. Rudy , "Mathematical Model of the Dependence of Heart Rate on the Tissue Concentration of Acetylcholine" Am J Physiol 1989; 256 (Heart Circ Physiol 25): H520-H526. PMID: 2916685

W. Quan and Y. Rudy , "Unidirectional Block and Reentry of Cardiac Excitation-A Model Study" Circulation Research 1990; 66: 367-382. PMID: 2297808

W. Quan and Y. Rudy , "Termination of Reentrant Propagation by a Single Stimulus - A Model Study" PACE 1991; 14: 1700-1706. PMID: 1721161

Y. Rudy
and W. Quan, "Propagation Delays Across Gap Junctions and their Reflection in Extracellular Potentials: a Simulation Study" J Cardiovascular Electrophysiology 1991; 2: 299-315.

C. Luo and Y. Rudy , "A Model of the Ventricular Cardiac Action Potential: Depolarization, Repolarization and their Interaction" Circulation Research 1991; 68: 1501-1526. PMID: 1709839

A. Shimizu, A. Nozaki, Y. Rudy , and A.L. Waldo, "Multiplexing Studies of the Effects of Rapid Atrial Pacing on the Area of Slow Conduction During Atrial Flutter in the Canine Pericarditis Model" Circulation 1991; 83: 983-994.

A. Shimizu, A. Nozaki, Y. Rudy and A.L. Waldo, "Onset of Induced Atrial Flutter in the Canine Pericarditis Model" J Amer College Cardiol 1991; 17: 1223-1234. PMID: 2007723

F. Dexter, Y. Rudy , M.N. Levy, and E.N. Bruce, "Mathematical Model of Cellular Basis for the Respiratory Sinus Arrhythmia" J Theor Biol 1991; 150: 157-173. PMID: 1890853

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Y. Rudy
and R.Plonsey, "A note on the Brody-Effect" J Electrocardiology 1978; 11: 87-90. PMID: 621462

Y. Rudy
and R. Plonsey, "The Eccentric Spheres Model as the Basis for a Study of the Role of Geometry and Inhomogeneities in Electrocardiography" IEEE Trans Biomed Eng BME 1979; 26: 392-399. PMID: 457171

Y. Rudy
, R. Plonsey, and J. Liebman, "The Effects of Variations in Conductivity and Geometrical Parameters on the Electrocardiogram, Utilizing an Eccentric Spheres Model" Circ Res 1979; 44: 104-111. PMID: 758226

R. Plonsey and Y. Rudy , "Electrocardiogram Sources in a 2-Dimensional Anisotropic Activation Model" Medical and Bio Eng and Comp 1980; 18: 87-94. PMID: 7382595

Y. Rudy
and R. Plonsey, "A Comparison of Volume Conductor and Source Geometry Effects on Body Surface and Epicardial Potentials" Circ Res 1980; 46: 283-291. PMID: 6444278

and R. Plonsey, "Comments on the Effect of Variations in the Size of the Heart on the Magnitude of ECG PotentialsJ Electrocardiology   1980; 13: 79-82. PMID: 6444658

P. Diaz, Y. Rudy , and R. Plonsey, "A Model Study of the Effect of the Intercalated Discs on Discontinuous Propagation in Cardiac Muscle" Advances in Experimental Medicine and Biology 1983; 161 ("Myocardial Injury"): 79-90. PMID: 6869084

P. Diaz, Y. Rudy , and R. Plonsey, "The Intercalated Discs as a Cause for Discontinuous Propagation in Cardiac Muscle: A Theoretical Simulation" Annals of Biomedical Engineering 1983; 11: 177-189. PMID: 6670783

Y. Rudy
and W. Quan, "A Model Study of the Effects of the Discrete Cellular Structure on Electrical Propagation in Cardiac Tissue" Circ Res 1987; 61: 815-823. PMID: 3677338

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