Research

SINGLE CHANNEL MARKOV DESCRIPTIONS

Genetic defects in membrane ion channels can disrupt the delicate balance of dynamic interactions between the ion channels and the cellular environment leading to altered cell function. As ion-channel defects are typically studied in expression systems, away from the cellular environment where they function physiologically, a connection between molecular findings and the physiology and pathophysiology of the cell is rarely established. We use a single-channel-based Markovian modeling approach to bridge this gap. We achieve this by determining the cellular arrhythmogenic consequences of mutations in Markovian current models that modularly replace Hodgkin-Huxley currents in the Luo-Rudy ventricular model.

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