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Yoram Rudy Lab

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Calcium Cycling

Overview Chart | Cells & Ion Channels | Calcium Cycling | Regulatory Pathways

Calcium Cycling in Cardiac Myocytes

Please click the following links to download codes

♦ LRd with Markov L-type Ca2+ channel and Ryanodine receptor, 2007
Related article: Faber GM, Silva J, Livshitz L, Rudy Y. “Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation”. Biophys J. 2007 Mar 1;92(5):1522-43. Epub 2006 Dec 8.
Download: Matlab Simulink code;  C++ code

♦ LRd/HRd with role of CaMKII and alternans, 2007
Related article: Livshitz LM, Rudy Y. “Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents”. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2854-66. Epub 2007 Feb 2.
Download:  Matlab code for LRd;  Matlab code for HRd

♦  Local stochastic Ca2+ release processes, 2011
Related article:Gaur N, Rudy Y. “Multiscale modeling of calcium cycling in cardiac ventricular myocyte: macroscopic consequences of microscopic dyadic function”. Biophys J. 2011 Jun 22;100(12):2904-12.
Download: C++ code

♦ PRd orginal purkinje model, 2011
Related article: Li P, Rudy Y. “A model of canine purkinje cell electrophysiology and Ca2+ cycling: rate dependence, triggered activity, and comparison to ventricular myocytes”. Circ Res. 2011 Jun 24;109(1):71-9. Epub 2011 May 12.
Download: C++ code

  • Research
    • Basic Mechanisms of Cardiac Excitation Arrhythmias
      • Models and Simulations
      • Model Codes
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    • Noninvasive Electrocardiographic Imaging (ECGI)
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Yoram Rudy, PhD, FAHA, FHRS

The Fred Saigh Distinguished Professor of Engineering

Professor of Biomedical Engineering

Director of the Cardiac Bioelectricity & Arrhythmia Center (CBAC)

rudy@wustl.edu

mailing address

Cardiac Bioelectricity & Arrhythmia Center
Department of Biomedical Engineering
MSC 1097-202-190
Washington University
1 Brookings Drive
St. Louis, MO 63130-4899
314-935-7887
314-935-7448 (fax)

 

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