Regulatory Pathways in Cardiac Myocytes

Hund-Rudy original canine ventricular model with CaMK, 2004
– Related article: Hund TJ, Rudy Y. “Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model”. Circulation 2004; 110:3168-3174.
– Download: Matlab code; C++ code

♦ LRd/HRd with role of CaMKII and alternans, 2007
– Related article: Livshitz LM, Rudy Y. “Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents“. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2854-66. Epub 2007 Feb 2.
– Download: Matlab code for LRd, Matlab code for HRd

♦ HRd model for abnormal Ca2+ homeostasis, 2008
– Related article: Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, Rudy Y. “Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling”. J Mol Cell Cardiol. 2008 Sep;45(3):420-8. Epub 2008 Jun 28.
– Download: C++ code

♦ β-adrenergic signaling cascade, 2011
– Related article: Heijman J, Volders PG, Westra RL, Rudy Y. “Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient“. J Mol Cell Cardiol. 2011 May;50(5):863-71.
– Download: Matlab code