List of Models for Ion Channels, Myocytes and Regulatory Pathways

(Please click the following links to download codes)

♦ ORd orginal human ventricular model, 2011
Related article: O’Hara T, Virág L, Varró A, Rudy Y. “Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation”. PLoS Comput Biol. 2011 May;7(5):e1002061. Epub 2011 May 26.
Download: Matlab code; C++ code

♦ PRd orginal purkinje model, 2011
Related article: Li P, Rudy Y. “A model of canine purkinje cell electrophysiology and Ca2+ cycling: rate dependence, triggered activity, and comparison to ventricular myocytes”. Circ Res. 2011 Jun 24;109(1):71-9. Epub 2011 May 12.
Download: C++ code

♦  β-adrenergic signaling cascade, 2011
Related article: Heijman J, Volders PG, Westra RL, Rudy Y. “Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient”. J Mol Cell Cardiol. 2011 May;50(5):863-71.
Download: Matlab code

♦ Local stochastic Ca2+ release processes, 2011
Related article: Gaur N, Rudy Y. “Multiscale modeling of calcium cycling in cardiac ventricular myocyte: macroscopic consequences of microscopic dyadic function”. Biophys J. 2011 Jun 22;100(12):2904-12.
Download: C++ code

♦ HRd model for infarct border zone, 2010
Related article: Decker KF, Rudy Y. “Ionic mechanisms of electrophysiological heterogeneity and conduction block in the infarct border zone”. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1588-97. Epub 2010 Aug 13.
Download: Matlab code; C++ code

♦ LRd model for hypoxia, 2009
Related article: Gaur N, Rudy Y, Hool L. “Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia”. Circ Res. 2009 Dec 4;105(12):1196-203. Epub 2009 Oct 29.
Download: C++ code

♦ LRd steady state analysis, 2009
Related article: Livshitz LM, Rudy Y. “Uniqueness and stability of action potential models during rest, pacing, and conduction using problem-solving environment”. Biophys J. 2009 Sep 2;97(5):1265-76.
Download: Matlab code

♦ HRd single cell and strand rate-dependent behaviors and restitution, 2009
Related article: Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y, “Properties and Ionic Mechanisms of Action Potential Adaptation, Restitution and Accommodation in Canine Epicardium” Am J Physiol Heart Circ Physiol 2009; 296:1017-1026. Epub 2009 Jan 23.
Download: Matlab code; C++ code

♦ HRd model for abnormal Ca2+ homeostasis, 2008
Related article: Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, Rudy Y. “Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling”. J Mol Cell Cardiol. 2008 Sep;45(3):420-8. Epub 2008 Jun 28.
Download: C++ code

♦ LRd/HRd with role of CaMKII and alternans, 2007
Related article: Livshitz LM, Rudy Y. “Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents”. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2854-66. Epub 2007 Feb 2.
Download: Matlab code for LRdMatlab code for HRd

♦ LRd with Markov L-type Ca2+ channel and Ryanodine receptor, 2007
Related article: Faber GM, Silva J, Livshitz L, Rudy Y. “Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation”. Biophys J. 2007 Mar 1;92(5):1522-43. Epub 2006 Dec 8.
Download: Matlab Simulink codeC++ code

♦ Markov model for IKr and IKs for LRd model, 2005
Related article: Silva J, Rudy Y. “Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve”. Circulation. 2005 Sep 6;112(10):1384-91. Epub 2005 Aug 29.
Download: Matlab code

♦ Hund-Rudy original canine ventricular model with CaMK, 2004
Related article: Hund TJ, Rudy Y. “Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model”. Circulation 2004; 110:3168-3174.
Download: Matlab codeC++ code

♦ LRd Nai overload analysis, 2000
Related article: Faber GM, Rudy Y. “Action potential and contractility changes in Na+i overloaded cardiac myocytes: a simulation study”. Biophys J. 2000 May;78(5):2392-404.
Download: C++ code

♦ Luo-Rudy original guinea pig ventricular model, 1991
Related article: Luo CH, Rudy Y. “A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction”. Circ Res. 1991 Jun;68(6):1501-26.
Download: Matlab code