1. |
To develop computational biology tools for the study of arrhythmia mechanisms at all levels of the cardiac system (ion-channel, cardiac cell, multicellular tissue, whole-heart).
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2. |
To use these tools, in combination with experimental data, to elucidate the mechanisms and simulate the arrhythmogenic consequences of hereditary (genetic) and acquired (environmental) cardiac disease.
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3. |
To simulate the effects of therapeutic interventions (drugs, genetic modification, pacing) on cardiac arrhythmias in an effort to help develop better strategies for therapy.
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4. |
To develop and validate a noninvasive imaging modality for cardiac arrhythmias (Electrocardiographic Imaging, ECGI) and to use this modality to study the mechanisms of arrhythmias and effects of antiarrhythmic interventions in humans.
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5. |
To provide training in the application of quantitative approaches to the research of cardiac arrhythmias and to the design/realization of novel diagnostic tools.
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6. |
To provide an environment for mechanism-based diagnosis of cardiac arrhythmias
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